R-454C is a Low GWP hydrofluoro-olefin (HFO) based refrigerant replacement for R404A and R22. R454C is a close match to R22 based technology, but it is also a valid solution for R404A equipment.
It is a blend of R-32 and R-1234yf in the following proportions: 21.5% R-32/78.5% R-1234yf.